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Osteoarthritis is the leading cause of poor performance in horses; therefore, veterinarians are always looking for novel treatment approaches because many currently available treatments are short-acting and only mild to moderately effective. Recently researchers examined a 2.5% polyacrylamide hydrogel (PAAG) and reported it clinically appealing due to its efficacy, long-lasting effect, and safety.
“This product is a medical device that has received product authorization from the FDA in 2020 for the treatment of osteoarthritis in horses,” said Aziz Tnibar, DVM, PhD, Dipl. ECVS, ACVSMR, ECVSMR, clinical director and head surgeon of The Equine Hospital-Riyadh, Jockey Club of Saudi Arabia, during his presentation at the 2023 American Association Equine Practitioners Convention, held Nov. 29-Dec. 3 in San Diego, California.
He explained that PAAG is a nontoxic and nonimmunogenic (does not produce an immune response) biocompatible biopolymer composed of hydrogel and water with no chemical activity.
“Compared to nonsteroidal anti-inflammatory drugs, corticosteroid anti-inflammatories, and the biologic therapies such as autologous conditioned serum (ACS), PAAG has a completely different mechanism of action, integrating into the synovial membrane, increasing joint capsule elasticity, and providing long-lasting viscosupplementation,”said Tnibar.
During his presentation Tnibar reviewed the following six published clinical studies on PAAG to provide practitioners with the available evidence-based information on this product:
“Treatment with PAAG was statistically superior with therapeutic effects persisting up to 12 weeks,” Tnibar said. Because OA is the most common cause of chronic joint pain and physical impairment in horses, effective therapies are necessary. Based on this clinical data, he added, PAAG has proven itself efficacious with long-lasting effects (up to two years) and safe, with an estimated 0.004% complication rate and only one reported transient complication.
“It is important that the diagnosis (of OA) is accurate, and good injection technique is imperative,” he added. “If PAAG is injected into synovial (joint) membrane instead of intra-articularly, it won’t be as effective.”
Editor’s note: The meeting Proceedings acknowledged in a conflict of interest statement that Tnibar has completed some research funded by Contura International A/S.
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